Abstract Radio occultation technology is an effective means of neutral atmospheric observation. This paper briefly introduces the basic flow of GPS-LEO neutral atmospheric radio occultation inversion. Considering the influence of various error sources on the inversion of atmospheric parameters, we use EGOPS simulation software to simulate 426 occultation events a day using 3D ray tracing method, analyzing the influence characteristics of many error sources. The statistical analysis of the inversion temperature shows that the stability of the satellite clock and the accuracy of the satellite orbit determination can meet the occultation inversion demand. The noise error has a great influence on the inversion, and effective measures are needed. For the multipath effect, the influence of the periodic error is small, but the amplitude has some influence on the inversion result, and it needs to be effectively suppressed.