We study crustal dynamic deformation in the Sichuan-Yunnan region based on 1999-2015 GNSS data of CMONOC and Sichuan province CORS network. We divide into six periods of 1999-2004, 2004-2007, 2007-2009, 2009-2011,2011-2013 and 2013-2015, establish three crustal deformation models respectively, and conduct the contrast analysis. The research shows that the crustal horizontal movement is mainly inherited movement in Sichuan-Yunnan region. The crustal movement trend and the acting force are not changed by the Wenchuan earthquake, but the velocity field variations are more complex with time and increase in magnitude. Especially on the west side of the Longmenshan fault, crustal movement velocity increases obviously after the Wenchuan earthquake. The strain rate and state show obvious dynamic characteristics with time, and the high value areas are mainly located around the deep faults such as the Longmenshan, Xianshuihe and Xiaojiang faults. It shows that the fracture activity has a significant influence on crustal deformation control in the Sichuan-Yunnan region.